In the past two decades, social media have drastically shaped our understanding and practice of health. From online patient blogs, Facebook, to YouTube, from Twitter, dating apps, to Instagram, and finally, from wearable devices to algorithmic computation, social media and technology offer new opportunities for people to exchange health information and yet pose new challenges to health interventions and public communication. This course is intended to provide an overview of theories and methods intersecting with social media and health. Following the historical development of social media, the course will cover health citizen engagement (information behaviors), contents (user-generated messages), platform governance (digital surveillance and resistance), and other aspects of social media related to health and healthcare. The course materials draw on the interdisciplinary perspectives from public health, communication studies, and science and technology studies. Students will learn how the use and design of social media might reinforce health inequality while critically evaluating different stakeholders’ standpoints. Students will also have a chance to analyze health campaigns and select communication strategies for different audiences and sectors. Overall, the course aims to provide students with theoretical lenses and practical tools to engage in meaningful health intervention. The course design also seeks to enhance students’ digital health literacy.